By Robert S. Matson
Microarrays play an more and more major position in drug discovery. Written by way of a pace-setter within the box, employing Genomic and Proteomic Microarray know-how in Drug Discovery highlights, describes, and evaluates present medical study utilizing microarray expertise in genomic and proteomic functions. the writer addresses the drawbacks, supporting you stay away from pointless pitfalls, and offers useful tips to hire the know-how in drug discovery and improvement. The publication information the industrial panorama, overlaying the numerous matters surrounding the longer term adoption of gene expression and protein microarrays for pharmacogenomic and pharmacoproteomic functions. the writer severely assesses these reports that experience helped outline functions in genomics and proteomics, explains gene expression microarray functions, and examines the software of the protein microarray. He covers replacement substrates and the instruction of assorted floor chemistries including their suitability for immobilization of nucleic acids and proteins. He delineates the mechanics of microarraying together with environmental stipulations, printer and pin functionality, in addition to dialogue concerning constructing the print run. The booklet offers protocols for printing nucleic acids and proteins and an in-depth dialogue of alternative vital parameters resembling print buffers (inks) and components influencing print caliber. An knowing of the making of a microarray is essentially vital to these attracted to generating "spotted" arrays and their right use. As this know-how expands in reputation and value, specialists needs to take hold of the basic rules at the back of it, its strengths, and its obstacles. A easy reference for clients of microarray know-how in drug discovery, this e-book bargains a close viewpoint and perception into the current and destiny makes use of of this expertise.
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Extra resources for Applying Genomic and Proteomic Microarray Technology in Drug Discovery
A total of 2009 genes common to all three platforms were analyzed. 50). 8 Microarray cross-platform showing differentially expressed gene clusters obtained from Amersham, Agilent, and Affymetrix products. K. , 31(19), 5676–5684, 2003. ” In another study, Barczak et al. (2003) compared GeneChip arrays to so-called “long” oligonucleotide arrays. A total of 7344 genes from the human genome were analyzed using the Affymetrix U95 GeneChip along with two spotted arrays comprising 70-mer probes (Operon Human Genome Oligo Set, versions 1 and 2).
Omic’ and hypothesis-driven research in the molecular pharmacology of cancer, Curr. , 2, 361–365, 2002. , Elevated HGF levels in sera from breast cancer patients detected using a protein microarray ELISA, J. , 1, 233–237, 2002. , Gene expression analysis as an aid to the identification of drug targets, Pharmacogenomics, 1(4), 375–384, 2000. Ziauddin, J. , Microarrays of cells expressing defined cDNAs, Nature, 411, 107–110, 2001. fm Page 31 Wednesday, November 17, 2004 11:01 AM chapter two Commercial microarrays Introduction In this chapter, we will review the commercialization of microarrays.
Synteni (founded by Stanford inventor Dari Shalon in 1994) was first to introduce custom microarray analysis based upon the new cDNA-based slide format termed gene expression microarray (GEM) technology. The company was later acquired by Incyte Genomics in 1997 and became Incyte Microarray Systems until the unit was purchased by Quark Biotech in 2002 for internal use for target discovery. In 1999, an overview of the microarray world titled “The Chipping Forecast” appeared as a supplement to Nature Genetics.