Download Acute Leukemias VI: Prognostic Factors and Treatment by J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. PDF

By J. D. Rowley (auth.), Prof. Dr. T. Büchner, Prof. Dr. G. Schellong, Prof. Dr. J. Ritter, Priv. Doz. Dr. U. Creutzig, Prof. Dr. W. Hiddemann, Priv. Doz. Dr. B. Wörmann (eds.)

For 10 years the e-book sequence Acute Leukemias has been delivering updates at the swift growth being made the world over relating this staff of ailments. The 5th quantity quite often addressed experimental ways, however the current factor offers either healing and prognostic points of the newest effects from significant multicenter scientific trials. extra chapters record new developments in leukemia telephone biology,the tracking of minimum residual ailment, and secondary leukemias, in addition to new antileukemic medicines, antimicrobial techniques, and using cytokines. The mixed efforts opposed to acute leukemias defined during this booklet clarify the new advancements within the end result of sufferers struggling with acute leukemias.

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O. Identification of a gene (MLL) which spans the breakpoint in IIq23 translocations associated with human leukemias. Proc Nat! Acad Sci USA 1991: 88: 10735-39. 10. , Canaani E. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL- 1 gene, related to Drosophila Trithorax, to the AF-4 gene. Cell 1992: 71: 701-08. I!. A. A trithorax-like gene is interrupted by chromosome II q23 translocations in acute leukemias. Nature Genetics 1992: 2: 113-18. 12. L. Involvement of a homolog of Drosophila Trithorax by llq23 chromosomal translocations in acute leukemias.

13. 14. 15. 16. 17. inversion 16 chromosome in acute myelogenous leukemia. Blood 83,1750-1756,1994 Berger R, Bernheim A, Ochoba-Noguera ME, Daniel M-T, Valensi F, Siguax F, Flandrin G, Boiron M: Prognostic significance of the chromosomal abnormalities in acute nonlymphocytic leukemia: A study of 343 patients. Cancer Genet Cytogenet28,293-299,1987 Swans bury GJ, Lawler SD, Alimena G, Arthur D, Berger R, Van Den Berghe H, Bloomfield CD, De la Chappelle A, Dewald G, Garson OM, Hagemeijer A, Mitelman F, Rowley JD, Sakurai M: Long-term survival in acute myelogenous leukemia.

However, as yet, no direct proof of genetic defects in leukemic stem cells is available. In de novo AML with a differentiated phenotype, the leukemic transformation is thought to occur in cells at the maturational stage of the bulk leukemic population. The phenotype of the (pre)leukemic stem cell in AML and MDS has not been identified as yet. However, in normal human bone marrow immature hematopoietic precursors can be identified by the expressional pattern of the cell surface marker molecules CD34 and eD3S [2].

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